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Filtered Search Results
Apexbio Technology LLC GDC-0941 957054-30-7 200mg
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GDC-0941 (CAS 957054-30-7) is a selective small-molecule inhibitor of class I phosphoinositide 3-kinase (PI3K) a critical component involved in the PI3K/Akt signaling pathway frequently dysregulated in cancer By competitively binding to the ATP-binding site of PI3K GDC-0941 inhibits generation of the downstream signaling molecule phosphatidylinositol-3 4 5-trisphosphate (PIP3) Exhibiting high selectivity against p110 / (IC50 approx 3 nM) and moderate selectivity for p110 (33 nM) and p110 (75 nM) GDC-0941 has demonstrated antiproliferative activity across diverse tumor cell lines in vitro (e g A2780 PC3 U87MG) and tumor growth inhibition in xenograft cancer models supporting its utility in cancer research
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Apexbio Technology LLC CP-673451 343787-29-1 200mg
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CP-673451 (CAS 343787-29-1) is an ATP-competitive inhibitor with specificity for platelet-derived growth factor receptors (PDGFR- / ) It exhibits inhibitory potency with IC50 values of 10 nM for PDGFR- and 1 nM for PDGFR- while demonstrating significantly less inhibition toward kinases such as VEGFR-1 VEGFR-2 Lck TIE-2 and EGFR In cellular assays CP-673451 effectively inhibits PDGFR- phosphorylation in PAE- cells (IC50 6 4 nM) and reduces c-kit activity in H526 cells at micromolar range Its anticancer efficacy has been established by suppressing tumor growth and vascularization in xenograft models indicating its potential utility in cancer research and angiogenesis studies
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Apexbio Technology LLC Tideglusib 865854-05-3 200mg
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Tideglusib is a potent selective inhibitor of glycogen synthase kinase-3 (GSK-3 ) functioning through irreversible and ATP-noncompetitive inhibition with reported IC50 of 60 nM Mechanistically Tideglusib binds in a manner independent of ATP leading to sustained enzyme inactivation Preclinical studies utilizing animal models demonstrate Tideglusib s ability to attenuate hyperphosphorylation of Tau protein reduce amyloid plaque accumulation prevent neuronal loss and enhance cognitive performance Currently undergoing clinical investigation Tideglusib has advanced through Phase II studies for Alzheimer s disease (AD) and progressive supranuclear palsy (PSP) exploring therapeutic applicability related to its GSK-3 inhibition activity
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000346334 ROMACICLIB MONOHYDR 10MM 1ML
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eMolecules EMOLECULES INC
5000470617 4-4 6-DIMETHOXY-1 3 5-TRI 25G
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eMolecules 7-BROMOQUINOLINE 25G
5000162472 7-BROMOQUINOLINE 25G
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TARGETMOL CHEMICALS INC Triclabendazole 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Triclabendazole (CGA89317) has been used in trials studying Parasitic Disease. Purity 98.35%
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Apexbio Technology LLC LY2886721 1262036-50-9 200mg
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LY2886721 (CAS 1262036-50-9) is an orally bioavailable inhibitor of -site amyloid precursor protein cleaving enzyme 1 (BACE1) an aspartyl protease integral to amyloid precursor protein (APP) cleavage and amyloid- (A ) generation LY2886721 inhibits BACE1 activity with an IC50 of approximately 20 3 nM effectively reducing soluble APP and elevating soluble APP in human cell models (HEK293Swe) and neuronal cultures (PDAPP) at IC50 values of 18 7 nM and 10 7 nM respectively In animal models such as PDAPP mice oral LY2886721 administration dose-dependently reduces cerebral A C99 and sAPP levels Due to its BACE1 inhibitory action LY2886721 serves as a valuable tool in Alzheimer s disease research and therapeutic development
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Apexbio Technology LLC NSC 74859 501919-59-1 200mg
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NSC 74859 (CAS 501919-59-1) also known as S3I-201 is a selective inhibitor of the signal transducer and activator of transcription 3 (Stat3) pathway S3I-201 disrupts Stat3 DNA-binding activity exhibiting an IC50 of 86 M in vitro with minimal inhibitory effects on Stat1 and Stat5 It also impedes the formation of Stat1-Stat3 and Stat1-Stat1 complexes with IC50 values of 160 M and 300 M respectively In NIH 3T3/v-Src fibroblasts S3I-201 reduces constitutive Stat3 activation and pTyr-705 Stat3 levels induces apoptosis at 30 100 M and downregulates cyclin D1 Bcl-xL and survivin expression This compound is widely utilized in research to interrogate Stat3 function in cellular transformation and oncogenic signaling pathways
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000439746 FIRMONERTINIB MESYL 1G
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Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 1mg, CAS: 130370-60-4.
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Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development
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Medchemexpress LLC α-N-carbobenzoxy-L-lysine thiobenzyl ester monohydrochloride | 69861-89-8 | MFCD00058089 | 99.7% | C21H27ClN2O3S | 10MG
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Z-LYS-SBZL monohydrochloride is the monohydrochloride salt of a carbobenzoxy-protected lysine thiobenzyl ester. Supplied as a solid research reagent, it is used in biochemical assays, protease and esterase activity studies, and peptide synthesis workflows where a protected lysine derivative is required.
- High purity suitable for analytical and preparative work
- Available in small-scale pack sizes for research use
- Stable when stored sealed and away from moisture
- Soluble in common organic solvents for reaction compatibility
- Useful as a substrate or intermediate in protease and peptide studies
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Apexbio Technology LLC Cytarabine(Synonyms: Ara-C, Cytosine arabinoside, Arabinosylcytosine, Cytosar-U, Cytosar, Depocyt), 200mg, CAS: 147-94-4.
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Cytarabine (CAS 147-94-4) also known as AraC is a nucleoside analog structurally related to deoxycytidine It acts primarily by incorporation into DNA subsequently hindering DNA synthesis via inhibition of DNA and RNA polymerases AraC requires phosphorylation by deoxycytidine kinase (dCK) to its active monophosphate metabolite Reduced dCK activity or expression of alternatively spliced inactive dCK isoforms has been linked to resistance in leukemic cell lines Additionally cytarabine induces apoptosis and inhibits cell proliferation involving p53 stabilization independent of transcriptional elevation as demonstrated in rat trophoblast cells Clinically cytarabine remains extensively studied in leukemia models and cellular apoptosis pathways
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eMolecules EMOLECULES INC
5000471888 2-QUINOLINECARBOXALDEHYDE 10G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000406091 ARGATROBAN MONOHYDR 10MM 1ML
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